Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy
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منابع مشابه
Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy.
I n t e r v e n t i o n Patients were allocated to once-daily losartanbased therapy (n = 660) or atenolol-based therapy (n = 666) with hydrochlorothiazide as the second agent in both groups to reach a target systolic BP < 140 mm Hg. M a i n o u t c o m e m e a s u r e s A composite endpoint of cardiovascular mortality, myocardial infarction (MI), and stroke. Secondary outcomes included all-caus...
متن کاملLosartan reduced stroke and new onset diabetes more than atenolol in essential hypertension with signs of left ventricular hypertrophy.
Patients 9222 patients 55–80 years of age (mean age 67 y, 54% women) with hypertension (sitting blood pressure [BP] of 160–200 mmHg systolic, 95–115 mm Hg diastolic, or both after 1–2 wks of placebo) and electrocardiographic signs of LVH. Exclusion criteria included secondary hypertension; myocardial infarction (MI) or stroke within the previous 6 months; angina pectoris requiring treatment wit...
متن کاملPulse pressure and effects of losartan or atenolol in patients with hypertension and left ventricular hypertrophy.
In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, the primary composite end point of cardiovascular death, stroke, and myocardial infarction was reduced by losartan versus atenolol in patients with hypertension and left ventricular hypertrophy. The objective of this post hoc analysis was to determine the influence of pulse pressure on outcome. Patients were divid...
متن کاملRegression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) Study.
BACKGROUND Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and regression of ECG LVH may predict improved prognosis in hypertensive patients. However, uncertainty persists as to how best to regress ECG LVH. METHODS AND RESULTS Regression of ECG LVH with losartan versus atenolol therapy was assessed in 9193 hypertensive patients with ECG...
متن کاملThe effects of losartan compared to atenolol on stroke in patients with isolated systolic hypertension and left ventricular hypertrophy. The LIFE study.
The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study reported that a losartan-based antihypertensive regimen reduced cardiovascular morbidity and mortality (composite of cardiovascular death, stroke, and myocardial infarction) more than therapy based on atenolol in patients with left ventricular hypertrophy and isolated systolic hypertension (ISH). Patients aged 55-80 y...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2003
ISSN: 1356-5524
DOI: 10.1136/ebm.8.2.43